Protein Details: G protein-activated inward rectifier potassium channel 1

Protein ID

ICDB_Pro_0558

Protein Name

G protein-activated inward rectifier potassium channel 1

Gene Name

KCNJ3; GIRK1

Organism

Homo sapiens (Human)

Length

501 amino acids

AlphaFoldDB

AF-P48549-F1-model_v4.pdb

Function

This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised;the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat

Sequence

MSALRRKFGDDYQVVTTSSSGSGLQPQGPGQDPQQQLVPKKKRQRFVDKNGRCNVQHGNLGSETSRYLSDLFTTLVDLKWRWNLFIFILTYTVAWLFMASMWWVIAYTRGDLNKAHVGNYTPCVANVYNFPSAFLFFIETEATIGYGYRYITDKCPEGIILFLFQSILGSIVDAFLIGCMFIKMSQPKKRAETLMFSEHAVISMRDGKLTLMFRVGNLRNSHMVSAQIRCKLLKSRQTPEGEFLPLDQLELDVGFSTGADQLFLVSPLTICHVIDAKSPFYDLSQRSMQTEQFEIVVILEGIVETTGMTCQARTSYTEDEVLWGHRFFPVISLEEGFFKVDYSQFHATFEVPTPPYSVKEQEEMLLMSSPLIAPAITNSKERHNSVECLDGLDDITTKLPSKLQKITGREDFPKKLLRMSSTTSEKAYSLGDLPMKLQRISSVPGNSEEKLVSKTTKMLSDPMSQSVADLPPKLQKMAGGAARMEGNLPAKLRKMNSDRFT

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Familial Atrial Fibrillation and Joubert Syndrome

Location

DOI ID

10.1085/jgp.107.3.381; 10.1016/0169-328x(95)00349-w; 10.1038/ng1285; 10.1038/nature03466; 10.1101/gr.2596504; 10.1074/jbc.m005338200

RefSeq

NP_001247437.1 [P48549-2]; NP_001247438.1; NP_001247439.1; NP_002230.1 [P48549-1]